The Third Domain Ligand Binding Fragment of Alpha-fetoprotein: Detection of Metastasis-associated Molecular Targets
نویسنده
چکیده
Human alpha-fetoprotein (AFP) was one of the first biomarkers developed as a cancer biomarker and is still today considered the “gold standard” biomarker for liver cancer. AFP is a glycopolypeptide exhibiting a molecular mass of 69 kD with a 3-5% carbohydrate content [1]. Structurally, the full-length AFP molecule consists of three domains forming nine layers of peptide loops configured by 15 cysteine disulfide bridges [2]. The twodimensional (secondary) image of AFP has been determined and been confirmed to be a Vor U-shaped molecular structure. Human AFP is classified as a member of the albuminoid gene family which consists of albumin, alpha-albumin, AFP, vitamin-D binding protein, and the AFP-related gene (ARG) protein [3]. Abstract
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